Highlighted Publications

Membrane proximal F-actin restricts local membrane protrusions and directs cell migration.

Bisaria A, Hayer A, Garbett D, Cohen D, Meyer T. Membrane proximal F-actin restricts local membrane protrusions and directs cell migration. Science 2020 Jun 12 DOI: 10.1126/science.aay7794

Molecular competition in G1 controls when cells simultaneously commit to terminally differentiate and exit the cell-cycle

Zhao ML, Rabiee A, Kovary KM, Bahrami-Nejad Z, Taylor B, Teruel MN. (2020). Cell Reports Jun 16;31(11):107769. doi: 10.1016/j.celrep.2020.107769. PMID: 32553172.

EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle.

Cappell SD, Mark KG, Garbett D, Pack LR, Rape M, Meyer T. EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle. Nature. 2018 Jun 6. doi: 10.1038/s41586-018-0199-7. PubMed PMID:29875408.

A transcriptional circuit filters oscillating circadian hormonal inputs to regulate fat cell differentiation.

Bahrami-Nejad Z*, Zhao ML*, Hunderdosse D, Tholen S, Tkach KE, van Schie S, Chung M, Teruel MN. A transcriptional circuit filters oscillating circadian hormonal inputs to regulate fat cell differentiation. Cell Metabolism. 2018 Apr 3, 27(4):854-868.e8. doi: 10.1016/j.cmet.2018.03.012. PubMed PMID: 29617644. *equal contribution.

Competing memories of mitogen and p53 signalling control cell-cycle entry.

Yang HW, Chung M, Kudo T, Meyer T. Competing memories of mitogen and p53 signalling control cell-cycle entry. Nature. 2017 Sept 21. doi: 10.1038/nature23880 PubMed PMID:28869970.

Controlling low rates of cell differentiation through noise and ultra-high feedback.

Ahrends R, Ota A, Kovary KM, Kudo T, Park BO, Teruel MN. Controlling low rates of cell differentiation through noise and ultra-high feedback. Science. 2014 Jun 20; 344:1384-9. PMID: 24948735. Awarded an Editors’ Choice rating by the Science magazine signaling editors.

2015 - Current

Membrane proximal F-actin restricts local membrane protrusions and directs cell migration.

Bisaria A, Hayer A, Garbett D, Cohen D, Meyer T. Membrane proximal F-actin restricts local membrane protrusions and directs cell migration. Science 2020 Jun 12 DOI: 10.1126/science.aay7794

Molecular competition in G1 controls when cells simultaneously commit to terminally differentiate and exit the cell-cycle

Zhao ML, Rabiee A, Kovary KM, Bahrami-Nejad Z, Taylor B, Teruel MN. (2020). Cell Reports Jun 16;31(11):107769. doi: 10.1016/j.celrep.2020.107769. PMID: 32553172.

Stress-mediated exit to quiescence restricted by increasing persistence in CDK4/6 activation

Yang HW, Cappell SD, Jaimovich A, Liu C, Chung M, Daigh LH, Pack LR, Fan Y, Regot S, Covert M, Meyer T. eLife 2020 Apr 7 .DOI: 10.7554/eLife.44571. PMC7213986

Transient Hysteresis in CDK4/6 Activity Underlies Passage of the Restriction Point in G1

Chung M, Liu C, Yang HW, Köberlin MS, Cappell SD, & Meyer T. Transient Hysteresis in CDK4/6 Activity Underlies Passage of the Restriction Point in G1. Molecular Cell 2019 Sept 19. doi: https://doi.org/10.1016/j.molcel.2019.08.020

A parallel cell-cycle entry pathway with inverted G1 signaling and alternate point of no return

Liu C, Konagaya Y, Chung M, Daigh LH, Fan Y, Yang HW, Terai K, Matsuda M, & Meyer T. A parallel cell-cycle entry pathway with inverted G1 signaling and alternate point of no return. BiorXiv. 2019 Apr 4. doi: https://doi.org/10.1101/600007

Putting the brakes on the cell cycle: mechanisms of cellular growth arrest

Pack LR, Daigh LH, Meyer T. Putting the brakes on the cell cycle: mechanisms of cellular growth arrest. Curr Opin Cell Biol. 2019 Jun 25 60 106-113. DOI: 10.1016/j.ceb.2019.05.005. PMCID: PMC7187785

The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity

Gan L, Seki A, Shen K, Iyer H, Han K, Hayer A, Wollman R, Ge X, Lin JR, Dey G, Talbot WS, Meyer TM. The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity. Nat. Cell Biol. 2019 Apr 29. doi: 10.1038/s41556-019-0321-6 PubMed PMID: 31036939

Efficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization

Tsai TY, Collins SR, Chan CK, Hadjitheodorou A, Lam PY, Lou SS, Yang HW, Jorgensen J, Ellett F, Irimia D, Davidson MW, Fischer RS, Huttenlocher A, Meyer T, Ferrell JE Jr, Theriot JA. Efficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization. Dev Cell. 2019 Apr 22. 49, 189-205. DOI: 10.1016/j.devcel.2019.03.025 PMC6708378.

An intrinsic S/G2 checkpoint enforced by ATR

Saldivar JC, Hamperl S, Bocek MJ, Chung M, Bass TE, Cisneros-Soberanis F, Samejima K, Xie L, Paulson JR, Earnshaw WC, Cortez D, Meyer T, Cimprich KA. An intrinsic S/G2 checkpoint enforced by ATR. Science. 2018 Aug 24 DOI: 10.1126/science.aap9346 PMC6365305.

Stochastic Endogenous Replication Stress Causes ATR-Triggered Fluctuations in CDK2 Activity that Dynamically Adjust Global DNA Synthesis Rates.

Daigh LH*, Liu C*, Chung M, Cimprich KA, Meyer T. Stochastic Endogenous Replication Stress Causes ATR-Triggered Fluctuations in CDK2 Activity that Dynamically Adjust Global DNA Synthesis Rate. Cell Systems. 2018 Jul 25. doi: 10.1016/j.cels.2018.05.011. PubMed PMID:29909278.

EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle.

Cappell SD, Mark KG, Garbett D, Pack LR, Rape M, Meyer T. EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle. Nature. 2018 Jun 6. doi: 10.1038/s41586-018-0199-7. PubMed PMID:29875408.

A transcriptional circuit filters oscillating circadian hormonal inputs to regulate fat cell differentiation.

Bahrami-Nejad Z*, Zhao ML*, Hunderdosse D, Tholen S, Tkach KE, van Schie S, Chung M, Teruel MN. A transcriptional circuit filters oscillating circadian hormonal inputs to regulate fat cell differentiation. Cell Metabolism. 2018 Apr 3, 27(4):854-868.e8. doi: 10.1016/j.cmet.2018.03.012. PubMed PMID: 29617644. *equal contribution.

Transcription-coupled changes in nuclear mobility of mammalian cis-regulatory elements

Gu B, Swigut T, Spencley A, Bauer MR, Chung M, Meyer T, Wysocka J. Transcription-coupled changes in nuclear mobility of mammalian cis-regulatory elements. Science. 2018 Mar 02. 359, 1050-1055. DOI: 10.1126/science.aao3136 PMC6590518.

Competing memories of mitogen and p53 signalling control cell-cycle entry.

Yang HW, Chung M, Kudo T, Meyer T. Competing memories of mitogen and p53 signalling control cell-cycle entry. Nature. 2017 Sept 21. doi: 10.1038/nature23880 PubMed PMID:28869970.

Measuring Signaling and RNA-Seq in the Same Cell Links Gene Expression to Dynamic Patterns of NF-κB Activation.

Lane K1*, Van Valen D*, DeFelice MM, Macklin DN, Kudo T, Jaimovich A, Carr A, Meyer T, Pe'er D, Boutet SC, Covert MW. Measuring Signaling and RNA-Seq in the Same Cell Links Gene Expression to Dynamic Patterns of NF-κB Activation. Cell Syst. 2017 April 26. doi: 10.1016/j.cels.2017.03.010 PubMed PMID:28396000.

Engulfed cadherin fingers are polarized junctional structures between collectively migrating endothelial cells.

Hayer A, Shao L, Chung M, Jouber LM, Yang HW, Tsai FC, Bisaria A, Betzig E, Meyer T. Engulfed cadherin fingers are polarized junctional structures between collectively migrating endothelial cells. Nat Cell Biol. 2016 Nov 14. doi: 10.1038/ncb3438 PubMed PMIDL27842057

Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion.

Malmersjö S, di Palma S, Diao J, Pfuetzner RA, Wang AL, McMahon MA, Hayer A, Proteus M, Brunger AT, Meyer T. Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion. EMBO J. 2016 Jul 11. doi: 10.15252/embj.201694071. PubMed PMID:27402227

Irreversible APC(Cdh1) Inactivation Underlies the Point of No Return for Cell-Cycle Entry.

Cappell SD, Chung M, Jaimovich A, Spencer SL, Meyer T. Irreversible APC(Cdh1) Inactivation Underlies the Point of No Return for Cell-Cycle Entry. Cell. 2016 Jun 30. doi: 10.1016/j.cell.2016.05.077. PubMed PMID:27368103.

Locally excitable Cdc42 signals steer cells during chemotaxis.

Yang HW*, Collins SR*, Meyer T. Locally excitable Cdc42 signals steer cells during chemotaxis. Nat Cell Biol. 2016 Feb 18. doi: 10.1038/ncb3292. PubMed PMID:26689677.

Waves of actin and microtubule polymerization drive microtubule-based transport and neurite growth before single axon formation.

Winans AM, Collins SR, Meyer T. Waves of actin and microtubule polymerization drive microtubule-based transport and neurite growth before single axon formation. Elife. 2016 Feb 2. doi: 10.7554/eLife.12387. PubMed PMID:26836307.

Systematic Discovery of Human Gene Function and Principles of Modular Organization through Phylogenetic Profiling.

Dey G, Jaimovich A, Collins SR, Seki A, Meyer T. Systematic Discovery of Human Gene Function and Principles of Modular Organization through Phylogenetic Profiling. Cell Reports. 2015 Nov 10. doi: 10.1038/nmeth.2729. PubMed PMID:25683721.

Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma.

Ge X, Milenkovic L, Suyama K, Hartl T, Purzner T, Winans A, Meyer T, Scott MP. Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma. Elife. 2015 Sept 15. doi: 10.7554/eLife.07068. PubMed PMID:26371509.

Phylogenetic Profiling for Probing the Modular Architecture of the Human Genome.

Dey G, Meyer T. Phylogenetic Profiling for Probing the Modular Architecture of the Human Genome. Cell Syst. 2015 Aug 26. doi: 10.1016/j.cels.2015.08.006. PubMed PMID:27135799.

Using light to shape chemical gradients for parallel and automated analysis of chemotaxis.

Collins SR, Yang HW, Bonger KM, Guignet EG, Wandless TJ , Meyer T. Using light to shape chemical gradients for parallel and automated analysis of chemotaxis. Mol Syst Biol. 2015 Feb 11. doi: 10.1016/j.celrep.2015.01.025. PubMed PMID:25908733.

2010 - 2015

Controlling low rates of cell differentiation through noise and ultra-high feedback.

Ahrends R, Ota A, Kovary KM, Kudo T, Park BO, Teruel MN. Controlling low rates of cell differentiation through noise and ultra-high feedback. Science. 2014 Jun 20; 344:1384-9. PMID: 24948735. Awarded an Editors’ Choice rating by the Science magazine signaling editors.

A polarized Ca2+, diacylglycerol and STIM1 signalling system regulates directed cell migration.

Tsai FC, Seki A, Yang HW, Hayer A, Carrasco S, Malmersjö S, Meyer T. Nat Cell Biol. 2014 Feb. doi: 10.1038/ncb2906. PubMed PMID:24463606.

Parallel measurement of dynamic changes in translation rates in single cells.

Han K, Jaimovich A, Dey G, Ruggero D, Meyuhas O, Sonenberg N, Meyer T. Nature Methods. 2014 January. doi: 10.1038/nmeth.2729. PubMed PMID:24213167.

The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit.

Spencer SL, Cappell SD, Tsai FC, Overton KW, Wang CL, Meyer T. Cell. 2013 Oct 10;155(2):369-83. doi: 10.1016/j.cell.2013.08.062. Epub 2013 Sep 26.

Dosage of Dyrk1a shifts cells within a p21-cyclin D1 signaling map to control the decision to enter the cell cycle.

Chen JY, Lin JR, Tsai FC, Meyer T. Mol Cell. 2013 Oct 10;52(1):87-100. doi: 10.1016/j.molcel.2013.09.009.

Regulators of calcium homeostasis identified by inference of kinetic model parameters from live single cells perturbed by siRNA.

Bandara S, Malmersjö S, Meyer T. Sci Signal. 2013 Jul 9;6(283):ra56. doi: 10.1126/scisignal.2003649.

Inside-out connections: the ER meets the plasma membrane.

Malmersjö S, Meyer T. Cell. 2013 Jun 20;153(7):1423-4. doi: 10.1016/j.cell.2013.05.054.

Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development.

Li W, Xiong Y, Shang C, Twu KY, Hang CT, Yang J, Han P, Lin CY, Lin CJ, Tsai FC, Stankunas K, Meyer T, Bernstein D, Pan M, Chang CP. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1738-43. doi: 10.1073/pnas.1218072110. Epub 2013 Jan 14.

Design of experiments to investigate dynamic cell signaling models.

Bandara S, Meyer T. Methods Mol Biol. 2012;880:109-18. doi: 10.1007/978-1-61779-833-7_7.

Cooperative activation of PI3K by Ras and Rho family small GTPases.

Yang HW, Shin MG, Lee S, Kim JR, Park WS, Cho KH, Meyer T, Heo WD. Mol Cell. 2012 Jul 27;47(2):281-90. doi: 10.1016/j.molcel.2012.05.007. Epub 2012 Jun 7.

Coordinated oscillations in cortical actin and Ca2+ correlate with cycles of vesicle secretion.

Wollman R, Meyer T. Nat Cell Biol. 2012 Dec;14(12):1261-9. doi: 10.1038/ncb2614. Epub 2012 Nov 11.

External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane.

Galic M, Jeong S, Tsai FC, Joubert LM, Wu YI, Hahn KM, Cui Y, Meyer T. Nat Cell Biol. 2012 Aug;14(8):874-81. doi: 10.1038/ncb2533. Epub 2012 Jul 1.

Spatial positive feedback at the onset of mitosis.

Santos SD, Wollman R, Meyer T, Ferrell JE Jr. Cell. 2012 Jun 22;149(7):1500-13. doi: 10.1016/j.cell.2012.05.028.

Ca2+ pulses control local cycles of lamellipodia retraction and adhesion along the front of migrating cells.

Tsai FC, Meyer T. Curr Biol. 2012 May 8;22(9):837-42. doi: 10.1016/j.cub.2012.03.037. Epub 2012 Apr 19.

A two-dimensional ERK-AKT signaling code for an NGF-triggered cell-fate decision.

Chen JY, Lin JR, Cimprich KA, Meyer T. Mol Cell. 2012 Jan 27;45(2):196-209. doi: 10.1016/j.molcel.2011.11.023. Epub 2011 Dec 28.

STIM proteins and the endoplasmic reticulum-plasma membrane junctions.

Carrasco S, Meyer T. Annu Rev Biochem. 2011;80:973-1000. doi: 10.1146/annurev-biochem-061609-165311.

Evolutionary origins of STIM1 and STIM2 within ancient Ca2+ signaling systems.

Collins SR, Meyer T. Trends Cell Biol. 2011 Apr;21(4):202-11. doi: 10.1016/j.tcb.2011.01.002. Epub 2011 Feb 1.

Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase.

Huang J, Birmingham CL, Shahnazari S, Shiu J, Zheng YT, Smith AC, Campellone KG, Heo WD, Gruenheid S, Meyer T, Welch MD, Ktistakis NT, Kim PK, Klionsky DJ, Brumell JH. Autophagy. 2011 Jan;7(1):17-26. Epub 2011 Jan 1.

A steering model of endothelial sheet migration recapitulates monolayer integrity and directed collective migration.

Vitorino P, Hammer M, Kim J, Meyer T. Mol Cell Biol. 2011 Jan;31(2):342-50. doi: 10.1128/MCB.00800-10. Epub 2010 Oct 25.

Cell biology: A sensor for calcium uptake.

Collins S, Meyer T. Nature. 2010 Sep 16;467(7313):283. doi: 10.1038/467283a.

The phosphoinositide phosphatase SopB manipulates membrane surface charge and trafficking of the Salmonella-containing vacuole.

Bakowski MA, Braun V, Lam GY, Yeung T, Heo WD, Meyer T, Finlay BB, Grinstein S, Brumell JH. Cell Host Microbe. 2010 Jun 25;7(6):453-62. doi: 10.1016/j.chom.2010.05.011.

High-content imaging.

Hayer A, Meyer T. Nat Biotechnol. 2010 May;28(5):424-5. doi: 10.1038/nbt0510-424.

Cracking CRAC.

Carrasco S, Meyer T. Cracking CRAC. Nat Cell Biol. 2010 May;12(5):416-8. doi: 10.1038/ncb0510-416.

2005 - 2010

Optimal experimental design for parameter estimation of a cell signaling model.

Bandara S, Schloder JP, Eils R, Bock HG, Meyer T. Optimal experimental design for parameter estimation of a cell signaling model. PLoS Comput Biol. 2009 Nov;5(11):e1000558. doi: 10.1371/journal.pcbi.1000558. Epub 2009 Nov 6.

Regulated RalBP1 binding to RalA and PSD-95 controls AMPA receptor endocytosis and LTD.

Han K, Kim MH, Seeburg D, Seo J, Verpelli C, Han S, Chung HS, Ko J, Lee HW, Kim K, Heo WD, Meyer T, Kim H, Sala C, Choi SY, Sheng M, Kim E. Regulated RalBP1 binding to RalA and PSD-95 controls AMPA receptor endocytosis and LTD. PLoS Biol. 2009 Sep;7(9):e1000187. doi: 10.1371/journal.pbio.1000187. Epub 2009 Sep 8.

A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability.

Paulsen RD, Soni DV, Wollman R, Hahn AT, Yee MC, Guan A, Hesley JA, Miller SC, Cromwell EF, Solow-Cordero DE, Meyer T, Cimprich KA. A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Mol Cell. 2009 Jul 31;35(2):228-39. doi: 10.1016/j.molcel.2009.06.021.

Quantitative analysis of cell cycle phase durations and PC12 differentiation using fluorescent biosensors.

Hahn AT, Jones JT, Meyer T. Quantitative analysis of cell cycle phase durations and PC12 differentiation using fluorescent biosensors. Cell Cycle. 2009 Apr 1;8(7):1044-52. Epub 2009 Apr 2.

Calcium flickers lighting the way in chemotaxis?

Collins SR, Meyer T. Calcium flickers lighting the way in chemotaxis. Dev Cell. 2009 Feb;16(2):160-1. doi: 10.1016/j.devcel.2009.01.018.

A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.

Rahdar M, Inoue T, Meyer T, Zhang J, Vazquez F, Devrotes PN. A phosphorylation-dependent intramolecular interaction regulates the membrane association and sctivity of the tumor suppressor PTEN. Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):480-5. doi: 10.1073/pnas.0811212106. Epub 2008 Dec 29.

Modular control of endothelial sheet migration.

Vitorino P, Meyer T. Modular control of endothelial sheet migration. Genes Dev. 2008 Dec 1;22(23):3268-81. doi: 10.1101/gad.1725808.

Feedback loops shape cellular signals in space and time.

Brandman O, Meyer T. Feedback loops shape cellular signals in space and time. Science. 2008 Oct 17;322(5900):390-5. doi: 10.1126/science.1160617.

Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration.

Inoue T, Meyer T. Synthetic activation of endogenous PI3K and Rac identifies and AND-gate switch for cell polarization and migration. PLoS One. 2008 Aug 27;3(8):e3068. doi: 10.1371/journal.pone.0003068.

Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane.

Chae YC, Kim JH, Kim KL, Kim HW, Lee HY, Heo WD, Meyer T, Suh PG, Ryu SH. Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane. Mol Biol Cell. 2008 Jul;19(7):3111-23. doi: 10.1091/mbc.E07-04-0337. Epub 2008 May 14.

A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size.

Kaplan DD, Zimmermann G, Suyama K, Meyer T, Scott MP. A nucleostemin family GTPas, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size. Genes Dev. 2008 Jul 15;22(14):1877-93. doi: 10.1101/gad.1670508.

Comprehensive identification of PIP3-regulated PH domains from C. elegans to H. sapiens by model prediction and live imaging.

Park WS, Heo WD, Whalen JH, O'Rourke NA, Bryan HM, Meyer T, Teruel MN. Comprehensive identification of PIP3-regulated PH domains from C. elegans to H. sapiens by model prediction and live imaging. Mol Cell. 2008 May 9;30(3):381-92. doi: 10.1016/j.molcel.2008.04.008.

Suspended-drop electroporation for high-throughput delivery of biomolecules into cells.

Guignet EG, Meyer T. Suspended-drop Electroporation for high-throughput delivery of biomolecues into cells. Nat Methods. 2008 May; 5(5):393-5.

Dissecting the role of PtdIns(4,5)P2 in endocytosis and recycling of the transferrin receptor.

Abe N, Inoue T, Galvez T, Klein L, Meyer T. Dissecting the role of PtdIns(4,5)P2 in endocytosis and recycling of the transferrin receptor. J Cell Sci. 2008 May 1;121(Pt 9):1488-94. doi: 10.1242/jcs.020792. Epub 2008 Apr 14.

Robust neuronal symmetry breaking by Ras-triggered local positive feedback.

Fivaz M, Bandara S, Inoue T, Meyer T. Robust neuronal symmetry breaking by Ras-triggered local positive feedback. Current Biology. 2008 Jan 8; 18(1):44-50. Epub 2007 Dec 27.

STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels.

Brandman O, Liou J, Park WS, Meyer T. STIM2 Is a Feedback Regulator that Stabilizes Basal Cytosolic and Endoplasmic Reticulum Ca(2+) Levels. Cell. 2007 Dec 28; 131(7):1327-29.

A transgenic mouse model for high content, cell cycle phenotype screening in live primary cells.

Burney RO, Lee AI, Leong DE, Jones JT, Hahn AT, Meyer T, Yao MW. A transgenic mouse model for high content, cell cycle phenotype screening in live primary cells. Cell Cycle. 2007 Sep 15;6(18):2276-83. Epub 2007 Jul 9.

siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptake.

Galvez, T., Teruel, M.N., Heo, WD, Jones, J.T., Kim, M.L., Liou, J., Myers, J.W., T. Meyer. 2007. siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptake. Genome Biol. Jul 19;8(7):R142

An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells.

Aoki, K., Nakamura, T., Inoue, T., Meyer, T., and M. Matsuda. 2007. An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells. J Cell Biol. Jun 4;177(5):817-27.

Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion.

Liou, J., Fivaz, M., Inoue, T., and T. Meyer. 2007. Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9301-6. Epub 2007 May 21.

The alliance for cellular signaling plasmid collection: a flexible resource for protein localization studies and signaling pathway analysis.

Zavzavadjian, J.R., Couture, S., Sun Park, W., Whalen, J., Lyon, S., Lee, G., Fung, E., Mi, Q., Liu, J., Wall, E., Santat, L., Dhandapani, K., Kivork, C., Driver, A., Zhu, X., Sook Chang, M., Randhawa, B., Gehrig, E., Bryan, H., Verghese, M., Maer, A., Saunders, B., Ning, Y., Subramaniam, S., Meyer, T., Simon, M.I., O'rourke, N., Chandy, G., and I.D. Fraser. 2007. The alliance for cellular signaling plasmid collection: a flexible resource for protein localization studies and signaling pathway analysis. Mol Cell Proteomics. 2007 Jan 5;

Participation of Rab5, an Early Endosome Protein, in Hepatitis C Virus RNA Replication Machinery.

Stone, M., Jia, S., Heo, W.D., Meyer, T., and K.V. Konan. 2007. Participation of Rab5, an Early Endosome Protein, in Hepatitis C Virus RNA Replication Machinery. Journal of Virology. Feb 4; 81: 4551-63.

A network of Rab GTPases controls phagosome maturation and is modulated by Salmonella enterica serovar Typhimurium.

Smith, A.C., Heo, W.D., Braun, V., Jiang, X., Macrae, C., Casanova, J.E., Scidmore, M.A., Grinstein, S., Meyer, T., and J.H. Brumell. 2007. A network of Rab GTPases controls phagosome maturation and is modulated by Salmonella enterica serovar Typhimurium. J. Cell Biol. Jan 29;176(3):263-8.

Cyclin A2 regulates nuclear-envelope breakdown and the nuclear accumulation of cyclin B1.

Gong, D., Pomerening, J.R., Myers, J.W., Gustavsson, C., Jones, J.T., Hahn, A.T., Meyer, T., and J.E. Ferrell. 2007. Cyclin A2 regulates nuclear-envelope breakdown and the nuclear accumulation of cyclin B1. Curr Biol. Jan 9;17(1):85-91.

PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane.

Heo, W.D., Inoue, T., Park, W.S., Kim, M.L., Park, B.O., Wandless, T.J., and T. Meyer. 2006. PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane. Science. 314(5804):1458-61.

Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels.

Suh, B.C., Inoue, T., Meyer, T., and B. Hille. 2006. Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels. Science. 314(5804):1454-7.

Interlinked fast and slow positive feedback loops drive reliable cell decisions.

Brandman, O., Ferrell, J.E. Jr, Li, R., and T. Meyer. 2005. Interlinked fast and slow positive feedback loops drive reliable cell decisions. Science 310(5747):496-8.

Spines and neurite branches function as geometric attractors that enhance protein kinase C action.

Craske, M.L., Fivaz, M., Batada, N.N., and T. Meyer. 2005. Spines and neurite branches function as geometric attractors that enhance protein kinase C action. J Cell Biol. 170(7):1147-58.

Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulin.

Fivaz, M. and T. Meyer. 2005. Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulin. J Cell Biol. 170(3):429-41.

STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx.

Liou, J., Kim, M.L., Heo, W.D., Jones, J.T., Myers, J.W., Ferrell, J.E. Jr, and T. Meyer. 2005. STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. Curr Biol. 15(13):1235-41.

An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways.

Inoue, T., Heo, W.D., Grimley, J.S., Wandless, T.J.,and T. Meyer. 2005. An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways. Nat Methods. 2(6):415-8.

Efficient chromosome capture requires a bias in the 'search-and-capture' process during mitotic-spindle assembly.

Wollman, R., Cytrynbaum, E.N., Jones, J.T., Meyer, T, Scholey, J.M., and A. Mogilner. 2005. Efficient chromosome capture requires a bias in the 'search-and-capture' process during mitotic-spindle assembly. Curr Biol. 15(9):828-32.

Protein localization studies in the age of 'Omics'.

O'rourke, N.A., Meyer, T., G. and Chandy. 2005. Protein localization studies in the age of 'Omics'. Curr Opin Chem Biol. 9(1):82-7.

A Local Coupling Model and Compass Parameter for Eukaryotic Chemotaxis.

Arrieumerlou, C. and T. Meyer. 2005. A Local Coupling Model and Compass Parameter for Eukaryotic Chemotaxis. Developmental Cell vol. 8: 215-227.

2000 - 2005

Simplified analogs of bryostatin with anticancer activity display greater potency for translocation of PKCdelta-GFP.

Baryza, J.L., Brenner, S.E., Craske, M.L., Meyer, T., and P.A. Wender. 2004. Simplified analogs of bryostatin with anticancer activity display greater potency for translocation of PKCdelta-GFP. Chem Biol. 11(9):1261-7.

A critical intramolecular interaction for protein kinase Cepsilon translocation.

Schechtman, D., Craske, M.L., Kheifets, V., Meyer, T., Schechtman, J., and Mochly-Rosen, D. 2004. A critical intramolecular interaction for protein kinase Cepsilon translocation. J. Biol Chem 279(16):15831-40.

The neural F-box protein NFB42 mediates the nuclear export of the herpes simplex virus type 1 replication initiator protein (UL9 protein) after viral infection.

Eom, C.Y., Heo, W.D., Craske, M.L., Meyer, T., and L.R. Lehman. 2004. The neural F-box protein NFB42 mediates the nuclear export of the herpes simplex virus type 1 replication initiator protein (UL9 protein) after viral infection. Proc Natl Acad Sci U S A. 101(12):4036-40.

Probing the precision of the mitotic clock with a live-cell fluorescent biosensor.

Jones, J.T., Myers, J.W., Ferrell, J.E., and Meyer, T. 2004. Probing the precision of the mitotic clock with a live-cell fluorescent biosensor. Nat Biotechnol. (3):306-12.

Specific localization and timing in neuronal signal transduction mediated by protein-lipid interactions.

Fivaz, M., and Meyer, T. 2003 Specific localization and timing in neuronal signal transduction mediated by protein-lipid interactions. Neuron. 40(2):319-30.

An ultrasensitive Ca2+/calmodulin-dependent protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signaling

Bradshaw, J.M., Kubota, Y., Meyer, T., and Schulman, H. An ultrasensitive Ca2+/calmodulin-dependent protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signaling. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10512-7. Epub 2003 Aug 19. DOI: 10.1073/pnas.1932759100. PubMed PMID: 12928489

Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII

Fink, C.C., Bayer, K.U., Ferrell, J.E. Jr., Schulman, H. and Meyer, T. Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII. Neuron. 2003 Jul 17;39(2):283-97. PubMed PMID: 12873385

Switch-of-function mutants based on morphology classification of Ras superfamily small GTPases

Heo, W.D. and Meyer, T. Switch-of-function mutants based on morphology classification of Ras superfamily small GTPases. Cell. 2003 May 2;113(3):315-28. PubMed PMID: 12732140

Recombinant Dicer efficiently converts large dsRNAs into siRNAs suitable for gene silencing.

Myers, J.W., Jones, J.T., Meyer, T., and Ferrell, J.E. Jr. Recombinant Dicer efficiently converts large dsRNAs into siRNAs suitable for gene silencing. Nat Biotechnol. 2003 Mar; 21(3):324-8. Epub 2003 Feb 18. DOI: 10.1038/nbt792. PubMed PMID: 12592410

Fluorescence imaging of signaling networks

Meyer, T. and Teruel, M.N. Fluorescence imaging of signaling networks. Trends Cell Biol. 2003 Feb;13(2):101-6. PubMed PMID: 12559761

Single cell imaging of PI3K activity and glucose transporter insertion into the plasma membrane by dual color evanescent wave microscopy

Tengholm, A., Teruel, M.N., and Meyer, T. Single cell imaging of PI3K activity and glucose transporter insertion into the plasma membrane by dual color evanescent wave microscopy. Sci STKE. 2003 Feb 11;2003(169):PL4. DOI: 10.1126/stke.2003.169.pl4. PubMed PMID: 12582202

A PI3-kinase signaling code for insulin-triggered insertion of glucose transporters into the plasma membrane.

Tengholm, A. and Meyer, T. A PI3-kinase signaling code for insulin-triggered insertion of glucose transporters into the plasma membrane. Curr Biol. 2002 Oct 29;12(21):1871-6. PubMed PMID: 12419189

Molecular mechanisms of CaMKII activation in neuronal plasticity.

Fink, C.C. and Meyer, T. Molecular mechanisms of CaMKII activation in neuronal plasticity. Curr Opin Neurobiol. 2002 Jun;12(3):293-9. PubMed PMID: 12049936

Parallel single-cell monitoring of receptor-triggered membrane translocation of a calcium-sensing protein module

Teruel, M.N. and T. Meyer. Parallel single-cell monitoring of receptor-triggered membrane translocation of a calcium-sensing protein module. Science. 2002 Mar 8; 295(5561):1910-2. DOI: 10.1126/science.1065028. PubMed PMID: 11884760

Active EGF receptors have limited access to PtdIns(4,5)P(2) in endosomes: implications for phospholipase C and PI 3-kinase signaling

Haugh, JM and Meyer, T. Active EGF receptors have limited access to PtdIns(4,5)P(2) in endosomes: implications for phospholipase C and PI 3-kinase signaling. J Cell Sci. 2002 Jan 15;115(Pt 2):303-10. PubMed PMID: 11839782

Control of astrocyte Ca(2+) oscillations and waves by oscillating translocation and activation of protein kinase C.

Codazzi, F., Teruel, M.N., and T. Meyer. Control of astrocyte Ca(2+) oscillations and waves by oscillating translocation and activation of protein kinase C. Curr Biol. 2001 Jul 24; 11(14):1089-97. PubMed PMID: 11509231

Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis

Marshall, J.G., J.W. Booth, V. Stambolic, T. Mak, T. Balla, A.D. Schreiber, T. Meyer, and S. Grinstein. Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis. J Cell Biol. 2001 Jun 25; 153(7):1369-80. DOI: 10.1083/jcb.153.7.1369. PubMed PMID: 11425868

Subcellular targeting by membrane lipids

Hurley, J.H. and Meyer, T. Subcellular targeting by membrane lipids. Curr Opin Cell Biol. 2001 Apr 1; 13(2):146-52. PubMed PMID: 11248547

Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis

Botelho, R.J., Teruel, M.N., Dierckman, R., Anderson, R., Wells, A., York, J.D., Meyer, T., and Gringstein, S. Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis. J Cell Biol. 2000 Dec 25; 151(7):1353-68. DOI: 10.1083/jcb.151.7.1353. PubMed PMID: 11134066

Spatial sensing in fibroblasts mediated by 3' phosphoinositides

Haugh, J.M., Codazzi, F., Teruel, M.N., and T. Meyer. Spatial Sensing in Fibroblasts Mediated by 3'Phosphoinositides. J Cell Biol. 2000 Dec 11; 151(6):1269-80. DOI: 10.1083/jcb.151.6.1269. PubMed PMID: 11121441

Translocation and reversible localization of signaling proteins: a dynamic future for signal transduction.

Teruel, M.N. and T. Meyer. Translocation and reversible localization of signaling proteins: a dynamic future for signal transduction. Cell. 2000 Oct 13; 103(2):181-4. PubMed PMID: 11057890

Molecular memory by reversible translocation of calcium/calmodulin-dependent protein kinase II

Shen, K., M. N. Teruel, J. H. Connor, S. Shenolikar, and T. Meyer. Molecular memory by reversible translocation of calcium/calmodulin-dependent protein kinase II. Nat Neurosci. 2000 Sep;3(9):881-6. DOI: 10.1038/78783. PubMed PMID: 10966618

Studies of signal transduction events using chimeras to green fluorescent protein

Meyer, T. and Oancea, E. Studies of signal transduction events using chimeras to green fluorescent protein. Methods Enzymol. 2000; 327:500-13. PubMed PMID: 11045005

In and out of the postsynaptic region: signalling proteins on the move

Meyer, T. and Shen, K. In and out of the postsynaptic region: signalling proteins on the move. Trends Cell Biol. 2000 Jun. 10(6):238-44. PubMed PMID: 10802539

Differential codes for free Ca(2+)-calmodulin signals in nucleus and cytosol.

Teruel MN, Chen W, Persechini A, Meyer T. Curr Biol. 2000 Jan 27;10(2):86-94.

Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion

Raucher, D., Stauffer, T., Chen, W., Shen, K., Guo, S., York, J.D., Sheetz, M.P., and T. Meyer. Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion. Cell. 2000 January 21. 100(2)L 221-8. doi: 10.1016/S0092-8674(00)81560-3. PubMed PMID: 10660045

1995 - 2000

A versatile microporation technique for the transfection of cultured CNS neurons.

Teruel MN, Blanpied TA, Shen K, Augustine GJ, Meyer T. J Neurosci Methods. 1999 Oct 30;93(1):37-48.

Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation.

Shen K, Meyer T. Science. 1999 Apr 2;284(5411):162-6.

Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium.

Improta-Brears T, Whorton AR, Codazzi F, York JD, Meyer T, McDonnell DP. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4686-91.

Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals.

Oancea E, Meyer T. Cell. 1998 Oct 30;95(3):307-18.

CaMKIIbeta functions as an F-actin targeting module that localizes CaMKIIalpha/beta heterooligomers to dendritic spines.

Shen K, Teruel MN, Subramanian K, Meyer T. Neuron. 1998 Sep;21(3):593-606.

Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt.

Kontos CD, Stauffer TP, Yang WP, York JD, Huang L, Blanar MA, Meyer T, Peters KG. Mol Cell Biol. 1998 Jul;18(7):4131-40.

Visualization of dynamic trafficking of a protein kinase C betaII/green fluorescent protein conjugate reveals differences in G protein-coupled receptor activation and desensitization.

Feng X, Zhang J, Barak LS, Meyer T, Caron MG, Hannun YA. J Biol Chem. 1998 Apr 24;273(17):10755-62.

Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells.

Stauffer TP, Ahn S, Meyer T. Curr Biol. 1998 Mar 12;8(6):343-6.

In vivo and in vitro characterization of the sequence requirement for oligomer formation of Ca2+/calmodulin-dependent protein kinase IIalpha.

Shen K, Meyer T. J Neurochem. 1998 Jan;70(1):96-104.

Characterization of a dextran-based bifunctional calcium indicator immobilized in cells by the enzymatic addition of isoprenoid lipids.

Horne JH, Meyer T. Cell Calcium. 1999 Jan;25(1):1-7.

Green fluorescent protein (GFP)-tagged cysteine-rich domains from protein kinase C as fluorescent indicators for diacylglycerol signaling in living cells.

Oancea E, Teruel MN, Quest AF, Meyer T. J Cell Biol. 1998 Feb 9;140(3):485-98.

Compartmentalized IgE receptor-mediated signal transduction in living cells.

Stauffer TP, Meyer T. J Cell Biol. 1997 Dec 15;139(6):1447-54.

Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular trafficking.

Thissen JA, Gross JM, Subramanian K, Meyer T, Casey PJ. J Biol Chem. 1997 Nov 28;272(48):30362-70.

Inhibition of Lyn function in mast cell activation by SH3 domain binding peptides.

Stauffer TP1 Martenson CH, Rider JE, Kay BK, Meyer T. Biochemistry. 1997 Aug 5;36(31):9388-94.

Electroporation-induced formation of individual calcium entry sites in the cell body and processes of adherent cells.

Teruel MN, Meyer T. Biophys J. 1997 Oct;73(4):1785-96.

Elementary calcium-release units induced by inositol trisphosphate.

Horne JH, Meyer T. Science. 1997 Jun 13;276(5319):1690-3.

Calcium-induced restructuring of nuclear envelope and endoplasmic reticulum calcium stores.

Subramanian K, Meyer T. Cell. 1997 Jun 13;89(6):963-71.

Control of action potential-induced Ca2+ signaling in the soma of hippocampal neurons by Ca2+ release from intracellular stores.

Jacobs JM, Meyer T. J Neurosci. 1997 Jun 1;17(11):4129-35.

Internal trafficking and surface mobility of a functionally intact beta2-adrenergic receptor-green fluorescent protein conjugate.

Barak LS, Ferguson SS, Zhang J, Martenson C, Meyer T, Caron MG. Mol Pharmacol. 1997 Feb;51(2):177-84.

Spatial dynamics of GFP-tagged proteins investigated by local fluorescence enhancement.

Yokoe H, Meyer T. Nat Biotechnol. 1996 Oct;14(10):1252-6.

Reversible desensitization of inositol trisphosphate-induced calcium release provides a mechanism for repetitive calcium spikes.

Oancea E, Meyer T. J Biol Chem. 1996 Jul 19;271(29):17253-60.

Luminal calcium regulates the inositol trisphosphate receptor of rat basophilic leukemia cells at a cytosolic site.

Horne JH, Meyer T. Biochemistry. 1995 Oct 3;34(39):12738-46.

Localized calcium signals in early zebrafish development.

Reinhard E, Yokoe H, Niebling KR, Allbritton NL, Kuhn MA, Meyer T. Dev Biol. 1995 Jul;170(1):50-61.

Regulation of nuclear calcium concentration.

Meyer T, Allbritton NL, Oancea E. Ciba Found Symp. 1995;188:252-62; discussion 262-6.

1990 - 1995

Source of nuclear calcium signals.

Allbritton NL, Oancea E, Kuhn MA, Meyer T. Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12458-62.

Dual role of calmodulin in autophosphorylation of multifunctional CaM kinase may underlie decoding of calcium signals.

Hanson PI, Meyer T, Stryer L, Schulman H. Neuron. 1994 May;12(5):943-56.

Localized calcium spikes and propagating calcium waves.

Allbritton NL, Meyer T. Cell Calcium. 1993 Nov;14(10):691-7.

Use of intracellular Ca2+ stores from rat basophilic leukemia cells to study the molecular mechanism leading to quantal Ca2+ release by inositol 1,4,5-trisphosphate.

Kindman LA, Meyer T. Biochemistry. 1993 Feb 9;32(5):1270-7.

Calmodulin trapping by calcium-calmodulin-dependent protein kinase.

Meyer T, Hanson PI, Stryer L, Schulman H. Science. 1992 May 22;256(5060):1199-202.

Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate.

Allbritton NL , Meyer T, Stryer L. Science. 1992 Dec 11;258(5089):1812-5.

Decoding calcium signals by multifunctional CaM kinase.

H.Schulman. P.I.Hanson T.Meyer. Cell Calcium Volume 13, Issues 6–7, June–July 1992, Pages 401-411

Association of the beta isoform of protein kinase C with vimentin filaments.

Spudich A, Meyer T, Stryer L. Cell Motil Cytoskeleton. 1992;22(4):250-6.

Cell signaling by second messenger waves.

Meyer T. Cell. 1991 Feb 22;64(4):675-8.

Calcium spiking.

Meyer, T. and Stryer, L. Ann. Rev. Biophys. Biophys. Chem. 20: 153-174.

Transient calcium release induced by successive increments of inositol 1,4,5-trisphosphate.

Meyer T, Stryer L. Proc Natl Acad Sci U S A. 1990 May;87(10):3841-5.

Kinetics of Calcium Channel Opening by Inositol 1,4,5-Trisphosphate.

Meyer, T., Wensel, T. G., and Stryer, L. 1990. Biochemistry 29: 32-37.

1985 - 1990

Highly Cooperative Opening of Calcium Channels by Inositol 1,4,5-Trisphosphate.

T Meyer, D Holowka, L Stryer; Science 29 Apr 1988: Vol. 240, Issue 4852, pp. 653-656

Molecular Model for Receptor-Stimulated Calcium Spiking

Meyer, T. and Stryer, L. 1988. Proc. Natl. Acad. Sci. USA 85: 5051-5055.

Particle Counting by Fluorescence Correlation Spectroscopy: Simultaneous Measurement of Aggregation and Diffusion of Molecules in Solutions and in Membranes..

Meyer, T. and Schindler, H. G. 1988. Biophys. J. 54: 983-993