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Yilin’s paper is out in Cell Reports!

July 27, 2021

Yilin’s paper is out in Cell Reports!

Molecular control of cell density-mediated exit to quiescence

Regulation of cell proliferation by cell density prevents uncontrolled cell expansion and maintains tissue size. Using live single-cell microscopy, we show that the decision of newborn daughter cells to proliferate or become quiescent is controlled by the memory of local cell density inherited from mother cells. This memory is mediated by density-dependent ERK signaling in mother cells and an ultrasensitive activator-inhibitor balance between cyclin D1 and p27 in daughter cells.